A highway and fallen leaves during autumn.

Fall Weekend Getaway in Cape

As the vibrant hues of autumn color the town and crisp breeze blows around the fallen leaves, there’s no better time to enjoy a relaxing fall weekend getaway in Cape Girardeau. With unique places to stay, eat and dine, there are endless possibilities to enjoy a fall weekend treat, filled with scenic beauty, outdoor adventures and moments of relaxation.

STAY

Before arriving in town, be sure to book the perfect place to rest after your fun-filled days. Cape is home to a great mix of accommodations, from large hotels to small, to historic rentals. And, the area’s only boutique hotel, Rockwood Inn, welcomes visitors to Cape Girardeau into a piece of history on Southeast Missouri State University’s campus. Built in 1921 as a private resident, then used by the university for decades, the home has now been renovated into a 7-bedroom hotel with common space – rent the whole house or just a room! For other options, visit the VisitCape Lodging Page.

To truly immerse yourself in the fall season, pitch a tent at Trail of Tears State Park with access to full hookups and basic tent sites. If you own an RV, you’ll have views of the Mighty Mississippi River at the park’s RV site location. What’s more fall than a roaring campfire, roasting marshmallows for s’mores, and waking up to dew on the grass!

EAT

Time to check out the local dining scene. Many local establishments have developed menus inspired by the season’s bounty. Savor a hearty meal and may be even save room for a pumpkin-inspired dessert.  Ebb and Flow Fermentations features an inviting outdoor patio, real wood fire pits and often eclectic live music Thursdays through Saturdays. Enjoy the fall foliage and weather while dining on an ever-evolving menu of seasonal features, but you’ll find things like a flatbread with apple butter, smoked chicken and white cheddar, or roasted sweet potatoes with berbere spice, chili aioli and feta! For more dining choices, visit our Dining Guide for delicious options.

DISCOVER

Cape’s Murals are one just aspect of Cape Girardeau’s vibrant arts community. While the fall afternoons bring warm temperatures, enjoy a stroll to appreciate the work and colorful depictions of these larger-than-life murals. There’s the Wall of Fame Mural along the Mississippi River Wall featuring 47 famous Missourians (think President Harry S. Truman and Jesse James). Or, admire the tile mural on the exterior of the Southeast Missourian newspaper building, which took 10 years to develop and two years to complete.

These examples are just a sampling of all there is to do and see in Cape. So, why wait? Plan your fall weekend getaway and immerse yourself in the magical embrace of autumn.

To see a calendar of events and happenings in town, be sure to visit our Events page!

Get the latest to your inbox!

Sign up to receive our seasonal newsletter where you’ll receive our latest blog posts!

This field is for validation purposes and should be left unchanged.
Send Emails(Required)

Adventures Await. Explore Events.

20Oct
Southeast Wind Symphony Presents: Church Windows
Tuesday, October 20, 2026 - Tuesday, October 20, 2026 07:30 PM - 09:30 PM Bedell Performance Hall 518 S Fountain Street
Details
21Oct
South Side Farms 573 Market
Wednesday, October 21, 2026 - Wednesday, October 21, 2026 10:00 AM - 02:00 PM South Side Farms 573 900 S West End Blvd, Cape Girardeau, MO, United States, 63703
Details
22Oct
Cape Farmer’s Market
Thursday, October 22, 2026 - Thursday, October 22, 2026 09:00 AM - 02:00 PM West Park Mall Parking Lot Mount Auburn Rd Entrance, Cape Girardeau, MO, United States, 63701
Details
22Oct
Louise Erdrich and William Faulkner Conference
Thursday, October 22, 2026 - Thursday, October 22, 2026 05:30 PM - 07:00 PM University Center 975 Normal Ave
Details
23Oct
SEMO Symphony Orchestra Presents: The Romantics
Friday, October 23, 2026 - Friday, October 23, 2026 07:30 PM - 09:30 PM Bedell Performance Hall 518 S Fountain Street
Details
23Oct
Kingdom Brothers – Broadway Blues
Friday, October 23, 2026 07:30 PM - 12:00 AM Scout Hall 420 Broadway Cape Girardeau, MO
Details
24Oct
Pets & Petals
Saturday, October 24, 2026 - Saturday, October 24, 2026 10:00 AM - 04:00 PM Show Me Center 1333 N Sprigg St, Cape Girardeau, MO 63701
Details
24Oct
Dresses To Die For : A Victorian Mourning Experience
Saturday, October 24, 2026 - Saturday, October 24, 2026 01:00 PM - 04:00 PM The Glenn House 325 S Spanish Street
Details
24Oct
Southeast Symphony Chamber Series Presents: Alexandra Joan in recital
Saturday, October 24, 2026 - Saturday, October 24, 2026 07:30 PM - 09:30 PM Shuck Music Recital Hall 518 S Fountain Street
Details
24Oct
Riverfront Fall Festival
Saturday, October 24, 2026 - Saturday, October 24, 2026 11:00 AM - 06:00 PM Downtown Cape Missouri Wall of Fame Lot, Cape Girardeau, MO
Details

Get the FREE VisitCape Visitor Guide to ensure your trip meets all your needs!

Get The Guide >

Fun for the Entire Family

Events in Cape >

Explore lodging & hotels

Places to Stay >