Embark on a scenic journey through Missouri, starting at the iconic Gateway Arch in St. Louis and winding through charming towns and historical sites, including Cape Girardeau, St. Charles, and the French Colonial town of Ste. Genevieve. Explore the region where Lewis and Clark entered Missouri Territory in 1803, marvel at breathtaking natural parks, and immerse yourself in the state’s rich history.
1. St. Louis
Begin your adventure in St. Louis at the Gateway Arch, a towering 630-foot monument symbolizing America’s westward expansion. Tour the Old Courthouse, home to the famous Dred Scott case, and explore nearby Laclede’s Landing, part of the original French settlement of St. Louis. For a taste of nature and culture, visit Forest Park, the site of the 1904 World’s Fair, featuring the Saint Louis Zoo, Art Museum, Science Center, and more. Other highlights include the Anheuser-Busch Brewery, Soulard Neighborhood, and the vibrant Grand Center district, home to theaters and museums, including the Fabulous Fox Theatre and Saint Louis University.
2. St. Charles
Next, travel to St. Charles, a quaint town that greeted Lewis and Clark’s expedition in 1804. Visit the Lewis & Clark Boat House, Museum, and Nature Center, where a full-size replica of the Corps’ keelboat and pirogues are displayed. Stroll through the historic district, home to Missouri’s first state capitol, antique shops, and the Foundry Art Centre with its rotating exhibits and studios.
3. Ste. Genevieve
Continue south to Ste. Genevieve, the oldest permanent European settlement in Missouri, founded in 1735. This picturesque town boasts over 100 historic homes and structures, award-winning wineries, and French-style restaurants. Visitors can also enjoy galleries, quaint shops, and the Great River Road Visitor Center, which provides detailed guides for the area.
4. Altenburg
Venture to the German settlement of Altenburg, located east of Uniontown. This historic site is home to Tower Rock, a natural landmark explored by Lewis and Clark. It’s an ideal stop for those fascinated by the explorers’ journey along the Mississippi River.
5. Cape Girardeau
Cape Girardeau, the largest city in southeast Missouri, was a key stop for Lewis and Clark. Visit the Red House Interpretive Center, a replica of the building where Lewis met trader Louis Lorimier. Explore the vibrant historic downtown, home to the Mississippi River Tales Mural and a variety of antique shops and restaurants. Don’t miss nearby Trail of Tears State Park, where the Corps camped in 1803. Other attractions include Bollinger Mill State Historic Site, Cape Girardeau Conservation Nature Center, and Historic Fort D, a Civil War defense site.
6. Charleston
In Charleston, visit the Lewis & Clark commemorative site, which features a granite map of the trail and murals celebrating the expedition’s arrival in Missouri. It’s a reflective stop highlighting the explorers’ pivotal journey through the region.
7. Arcadia Valley Auto Circle Tour
Take a detour from Cape Girardeau along State Highway 72 to explore the stunning natural beauty of Arcadia Valley. The scenic loop leads through Johnson’s Shut-Ins State Park, where volcanic rock chutes offer thrilling swimming adventures, and Taum Sauk Mountain State Park, Missouri’s highest point. Discover the towering Elephant Rocks State Park, where massive granite boulders line the landscape like elephants on parade.
8. Potosi
In Potosi, located in the Ozark Mountains near Mark Twain National Forest, outdoor enthusiasts can enjoy hiking, biking, and breathtaking views from Hughes Mountain. The area also offers adventures through the Berryman Recreation Area and the serene Bell Mountain Wilderness.
9. Sullivan/Stanton
Explore the underground wonders of Meramec Caverns near Stanton and enjoy the natural beauty of Meramec State Park in Sullivan. For thrill-seekers, zip lines over the Meramec River provide an unforgettable experience, while history buffs can visit the Jesse James Museum to learn about the infamous outlaw’s connection to the area.
10. Eureka
End your tour in Eureka, home to Six Flags St. Louis, known as the “Coaster Capital of Missouri.” Enjoy the town’s local shops and restaurants, and don’t miss nearby wildlife attractions, including the Endangered Wolf Center and the World Bird Sanctuary.
This Missouri Auto Tour offers a rich blend of history, nature, and adventure, taking you from the bustling city of St. Louis through charming small towns and scenic landscapes. Whether you’re a history lover or nature enthusiast, there’s something for everyone on this unforgettable journey through the heart of Missouri.